Washington University in St. Louis

Faculty Member, School of Medicine

Professor

About

My research group focuses on the pathogenesis and treatments for metabolic, anthropomorphic, and cardiovascular syndromes associated with HIV-infection, advanced age, and cachectic conditions. We utilize interdisciplinary resources and translational approaches to address patient and disease-oriented issues. We utilize stable isotope tracer methods and mass spectrometry, radioisotope tracer methods and positron emission tomography to quantify and characterize defects in substrate utilization and sensing in humans. We utilize several radiologic techniques to quantify adipose, lean, and bone mineral content and distribution in humans. Once metabolic, anthropomorphic, or cardiovascular syndromes have been characterized, we sample human tissues (muscle, fat, CSF) and utilize mass spectrometry-based analyses to identify and characterize protein, complex lipid, DNA, and RNA expression profiles that are dysregulated and may provide mechanistic information. The goal is to understand and describe the underlying pathogenesis for metabolic, anthropomorphic, and cardiovascular syndromes, so that safe and effective therapeutic interventions can be designed and tested.

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